Out FOXing Parkinson Disease: Where Development Meets Neurodegeneration
نویسندگان
چکیده
منابع مشابه
Out FOXing Parkinson Disease: Where Development Meets Neurodegeneration
P arkinson disease (PD) is the most common neurodegenerative movement disorder in humans, but its cause in the majority of patients is unknown. Fewer than 10% of cases appear to be inherited, and only rarely are the known Mendelian mutations identified in patients with PD. In addition to genetic factors, environmental toxins— especially those affecting mitochondrial function—have also been impl...
متن کاملWhere vascular meets neurodegenerative disease.
Vascular and neurodegenerative disease commonly cooccur in older persons. We review findings from the Rush Religious Orders Study and Memory and Aging Project. Both studies enroll subjects without diagnosed dementia, perform annual evaluations, and obtain autopsies proximate to death. We found that macroscopic infarcts are common, lower the threshold for cognitive impairment, and often coexist ...
متن کاملPathogenic mechanisms of neurodegeneration in Parkinson disease.
The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the substantia nigra that histologically characterize PD. α-Synuclein, the princi...
متن کاملNeurodegeneration across stages of cognitive decline in Parkinson disease.
OBJECTIVE To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD). DESIGN Images were quantified using a region-of-interest approach and voxel-based morphometry analysis. We used a high-dimensional pattern classification approach to delineate brain reg...
متن کاملWhere Structure Meets Function
5-Hydroxytryptamine 2 (serotonin 2 , 5-HT 2 )-family receptors are important for mediating many physiological functions, including vascular and nonvascular smooth muscle contraction, platelet aggregation, modulation of perception, mood, anxiety, and feeding behavior. A large number of psychopharmaceuticals, including atypical antipsychotic drugs, antidepressants, anxiolytics, and hallucinogens,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Biology
سال: 2007
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050334